Studies of Ascorbic Acid and Rheumatic Fever
نویسندگان
چکیده
In recent publications, Rinehart and Mettier (1933, 1934), and Rinehart, Connor and Mettier (1934) have offered evidence to the effect that chronic scurvy with superimposed infection in guinea pigs results in a histopathological picture "strikingly similar" to that found in rheumatic fever in human beings. Moreover, they have cited other experimental, epidemiological, and clinical data in favor of a theory that vitamin C deficiency may be a necessary accompaniment of the infection associated with this disease. Their experimental results with guinea pigs have, to some extent, been confirmed by Schultz (1936). The experimental evidence in favor of this concept is inadequate because no one has yet succeeded in producing rheumatic fever experimentally in any species, and because two different species have been used in an attempt to detect a pathological similarity between two different diseases-scurvy, and rheumatic fever. Furthermore, the other factors tending to make apparent a relationship between latent scurvy and rheumatic fever possess the limitations imposed upon any evidence of a purely presumptive nature. We have, therefore, endeavored to test this concept of Rinehart and his collaborators, by a direct study of the vitamin C 2 utilization in rheumatic and non-rheumatic patients. The present paper deals with the development of a method for the study of ascorbic acid nutrition in individuals,
منابع مشابه
Studies of Ascorbic Acid and Rheumatic Fever Ii. Test of Prophylactic and Therapeutic Action of Ascorbic Acid.
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